Rhys Nicholson

In 2011, Nicholson was featured in the ABC documentary GayCrashers alongside Joel Creasey, in which the duo travelled to the small town of Colac and performed a stand-up show. Creasey had been the subject of a homophobic attack on an earlier visit to the town.

Rhys Nicholson stars on the show The Weekly with Charlie Pickering.

In 2016, to highlight the importance of marriage equality in Australia, Nicholson publicly married lesbian and fellow comedian Zoe Coombs Marr at the Melbourne International Comedy Festival. That year Nicholson and Coombs Marr were also both nominated for the Barry Award for Best Show, which Coombs Marr won.

In 2021, Nicholson served as a judge on RuPaul's Drag Race Down Under, alongside RuPaul and Michelle Visage. The same year they appeared on the panel show Patriot Brains. In 2022, they played Doctor Sarkov in Netflix's Science-Fiction series The Imperfects.

In February 2024, Nicholson will be a contestant on the second series of Taskmaster Australia.