Tom Vilsack

On November 30, 2006, he formally launched his candidacy for the Democratic presidential nomination in the 2008 election, but ended his bid on February 23, 2007. President-elect Barack Obama announced Vilsack's selection to be Secretary of Agriculture on December 17, 2008. His nomination was confirmed by the United States Senate by unanimous consent on January 20, 2009. Until his January 13, 2017 resignation one week prior to the end of Obama's second term as president, he had been the only member of the U.S. Cabinet who had served since the day Obama originally took office.

On July 19, 2016, The Washington Post reported that Vilsack was on Hillary Clinton's two-person shortlist to be her running mate for that year's presidential election. U.S. Senator Tim Kaine from Virginia was ultimately selected. On December 10, 2020, President-elect Joe Biden announced his intention to nominate Vilsack to once again serve as secretary of agriculture in the incoming Biden administration. Vilsack was confirmed by the U.S. Senate on February 23, 2021, by a vote of 92–7. Currently Vilsack is the second longest serving Secretary of Agriculture, only being surpassed by fellow Iowan James "Tama Jim" Wilson.